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A hybrid structure determination approach to investigate the druggability of the nucleocapsid protein of SARS-CoV-2

17 Mar 2023

Abstract excerpt

The pandemic caused by SARS-CoV-2 has called for concerted efforts to generate new insights into the biology of betacoronaviruses to inform drug screening and development. Here, we establish a workflow to determine the RNA recognition and druggability of the nucleocapsid N-protein of SARS-CoV-2, a highly abundant protein crucial for the viral life cycle. We use a synergistic method that combines NMR spectroscopy...

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PMID: 36928389
DOI: 10.1093/nar/gkad195

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