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Article

Effect of CYP2C19 polymorphism on response to bortezomib-based therapy in multiple myeloma patients.

The American journal of the medical sciences - 1 Jul 2024

Goel Lavisha, Gupta Pooja, Kumar Lalit, Velpandian Thirumurthy, Singh Archana, Luthra Kalpana, Gupta Yogendra Kumar

Abstract excerpt

BACKGROUND: Bortezomib, a commonly used anti-myeloma drug, is metabolized by liver microsomal enzymes which may be polymorphic and responsible for lack of response in 30% patients. Hence, the association of CYP2C19 polymorphism with treatment response was explored in this study. METHODS: Treatment naive multiple myeloma (MM) patients, eligible for bortezomib-based induction treatment, were recruited as per the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38561047
DOI: 10.1016/j.amjms.2024.03.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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