Article
CYP2C19*2 gene variant (G681A, rs4244285) as a prognostic marker for the clinical course of multiple myeloma.
Experimental oncology - 1 Dec 2021
Kostiukova N I, Fishchuk L Ye, Rossokha Z I, Medvedieva N L, Andreieva S V, Bloshchinska S V, Popova O F, Vydyborets S V, Gorovenko N G
Abstract excerpt
BACKGROUND: Multiple myeloma (MM) is the most common type of paraproteinemic hemoblastosis, which is characterized by an aggressive course, high mortality and a large number of complications. The G681A variant (*2, rs4244285) of the CYP2C19 gene leads to the formation of an inactive enzyme and, as a consequence, may affect the development and course of MM. The aim of this research was to analyze the effect of the...
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