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Article

Heterozygous mutations in factor H aggravate pathological damage in a stable IgA deposition model induced by Lactobacillus casei cell wall extract.

Frontiers in immunology - 1 Jan 2024

Li Jingyi, Dong Yaping, Chen Feifei, Yang Hongyu, Chen Pei, Li Hongyu, Shi Sufang, Zhou Xujie, Zhu Li, Zhang Yuemiao, Liu Lijun, Xie Xinfang, Yu Feng, Jin Jing, Lv Jicheng, Zhang Hong

Abstract excerpt

Introduction: Activation of complement through the alternative pathway (AP) has a key role in the pathogenesis of IgA nephropathy (IgAN). We previously showed, by intraperitoneal injection of Lactobacillus casei cell wall extract (LCWE), C57BL/6 mice develop mild kidney damage in association with glomerular IgA deposition. To further address complement activity in causing glomerular histological alterations as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38558821
DOI: 10.3389/fimmu.2024.1368322
PMCID: PMC10978756

Genes

C3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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