Article
Complement factor H-point mutation promotes the development of preeclampsia-like phenotype with multiparity in mice.
Placenta - 1 Feb 2026
Chen Fei-Fei, Li Zheng, Tan Ying, Wang Hui, Chen Shi, Yu Feng, He Ying-Dong, Chen Qian, Yang Hui-Xia, Zhao Ming-Hui
Abstract excerpt
INTRODUCTION: Preeclampsia, a severe pregnancy disorder associated with the placenta, remains incompletely understood in terms of its pathogenesis. Studies have suggested a link between complement activation and preeclampsia. In normal pregnancy, there is a moderate balance between complement-activating factor and regulatory protein. Fourteen percent of patients with preeclampsia/hemolysis, elevated liver enzymes...
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