Article

The role of local complement factor H production in complement-mediated renal disease

2014-01-01

Abstract excerpt

The aim of my research was to define the roles of local and hepatic-derived factor H, in particular the contribution of extra-hepatic factor H to plasma C3 regulation and spontaneous renal disease associated with factor H deficiency. Factor H is the major soluble regulator of the alternative pathway of complement activation, synthesised predominantly by the liver. To investigate the role of extra-hepatic factor H,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 64c14480-279a-5470-b8fb-9a3c0544a44b
DOI: 10.25560/28078

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The role of local complement factor H production in complement-mediated renal diseaseDOI 10.25560/28078Read

Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic MicroangiopathySemantic proximity Read

Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.Semantic proximity Read

Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H.Semantic proximity Read

Elevated factor H–related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathySemantic proximity Read

Factor H related proteins modulate complement activation on kidney cellsSemantic proximity Read

Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domainsSemantic proximity Read

Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis.Semantic proximity Read

Of mice and men: The factor H protein family and complement regulationSemantic proximity Read

Mesangial immune complex glomerulonephritis due to complement factor D deficiency.Semantic proximity Read

Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy.Semantic proximity Read

Heterozygous mutations in factor H aggravate pathological damage in a stable IgA deposition model induced by Lactobacillus casei cell wall extract.Semantic proximity Read

Host recognition and target differentiation by factor H, a regulator of the alternative pathway of complementSemantic proximity Read