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Article

Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H.

Nature genetics - 1 Aug 2002

Pickering Matthew C, Cook H Terence, Warren Joanna, Bygrave Anne E, Moss Jill, Walport Mark J, Botto Marina

Abstract excerpt

The alternative pathway of complement is activated continuously in vivo through the C3 'tick-over' pathway. This pathway is triggered by the hydrolysis of C3, resulting in the formation of C3 convertase. This, in turn, generates C3b, which mediates many of the biological functions of complement....

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PMID: 12091909
DOI: 10.1038/ng912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12091909-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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