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Article

The CAF-1 and Hir Histone Chaperones Associate with Sites of Meiotic Double-Strand Breaks in Budding Yeast.

PloS one - 1 Jan 2015

Brachet Elsa, Béneut Claire, Serrentino Maria-Elisabetta, Borde Valérie

Abstract excerpt

In the meiotic prophase, programmed DNA double-strand breaks (DSB) are introduced along chromosomes to promote homolog pairing and recombination. Although meiotic DSBs usually occur in nucleosome-depleted, accessible regions of chromatin, their repair by homologous recombination takes place in a nucleosomal environment. Nucleosomes may represent an obstacle for the recombination machinery and their timely...

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Source

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Identifiers

PMID: 25938567
DOI: 10.1371/journal.pone.0125965
PMCID: PMC4418760

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Source receipt: pubmed, retrieved 7 Sept 2026.

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