EGFR Oncogenic Mutations in NSCLC Impair Macrophage Phagocytosis and Mediate Innate Immune Evasion Through Up-Regulation of CD47.

doi:10.1016/j.jtho.2024.03.019

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Article

EGFR Oncogenic Mutations in NSCLC Impair Macrophage Phagocytosis and Mediate Innate Immune Evasion Through Up-Regulation of CD47.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Aug 2024

Hu Li-Yang, Zhuang Wei-Tao, Chen Mao-Jian, Liao Jun, Wu Dong-Fang, Zhang Ya-Xiong, Pang Lan-Lan, Huang Yi-Hua, Mao Tian-Qin, Yang Meng-Juan, Peng Pei-Jian, Liang Jin-Xia, Chen Liang, Zeng Lin-Juan, Zhang Li, Fang Wen-Feng

Abstract excerpt

INTRODUCTION: EGFR-mutated NSCLC is characterized by an immunosuppressive microenvironment that confers limited clinical effectiveness to anti-PD-1 or PD-L1 antibodies. Despite the discouraging outcomes of immunotherapy, novel immune checkpoints are constantly emerging, among which the specific vulnerability for therapeutic intervention in the context of EGFR-mutated NSCLC remains unresolved. METHODS: Data sets...

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Identifiers

PMID: 38553005
DOI: 10.1016/j.jtho.2024.03.019

Genes

EGFR
CD47

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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