CD47 promotes mitogen-activated protein kinase and epithelial-to-mesenchymal transition molecular programs to drive prometastatic phenotypes in non-small cell lung cancer.

Abstract excerpt

CD47 is best known for its role in tumor immune evasion; however, studies in diverse cell models indicate that it also has cell autonomous, tumor-promoting functions which are cell type- and context-specific. Motivated by the prognostic and therapeutic significance of CD47 and the limited knowledge regarding its roles beyond immune evasion in non-small cell lung cancer (NSCLC), we sought to define the cellular...

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• Carcinoma, Non-Small-Cell Lung
• Cell Adhesion
• Cell Movement
• Epithelial-Mesenchymal Transition
• Gene Expression Regulation, Neoplastic