Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced Expression of CD47 Is Associated With Off-Target Resistance to Tyrosine Kinase Inhibitor Gefitinib in NSCLC.

Frontiers in immunology - 1 Jan 2019

Nigro Annunziata, Ricciardi Luca, Salvato Ilaria, Sabbatino Francesco, Vitale Monica, Crescenzi Maria Assunta, Montico Barbara, Triggiani Massimo, Pepe Stefano, Stellato Cristiana, Casolaro Vincenzo, Dal Col Jessica

Abstract excerpt

Mutual interactions between cancer cells and the tumor microenvironment importantly contribute to the development of tyrosine kinase inhibitor (TKI) resistance in patients affected by EGFR-mutant NSCLC. In particular, immune recognition-associated proteins with impact on tumor cell clearance through phagocytosis, such as CD47 and calreticulin, could contribute to adaptive resistance and immune escape. Preclinical...

Topics

Join the communities discussing this publication.

Antineoplastic Agents
Carcinoma, Non-Small-Cell Lung
Drug Resistance, Neoplasm
ErbB Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 32082304
DOI: 10.3389/fimmu.2019.03135
PMCID: PMC7004973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced Expression of CD47 Is Associated With Off-Target Resistance to Tyrosine Kinase Inhibitor Gefitinib in NSCLC.PMID 32082304Read ↗

CD47 promotes mitogen-activated protein kinase and epithelial-to-mesenchymal transition molecular programs to drive prometastatic phenotypes in non-small cell lung cancer.Semantic proximity Read ↗

EGFR Oncogenic Mutations in NSCLC Impair Macrophage Phagocytosis and Mediate Innate Immune Evasion Through Up-Regulation of CD47.Semantic proximity Read ↗

Advances in Anti-Tumor Treatments Targeting the CD47/SIRPα AxisSemantic proximity Read ↗

Targeted therapies prime oncogene-driven lung cancers for macrophage-mediated destruction.Semantic proximity Read ↗

CD47 expression is critical for CAR T-cell survival in vivoSemantic proximity Read ↗

A multidimensional pan-cancer analysis of CD47 and its role in promoting malignant phenotype in pancreatic adenocarcinoma.Semantic proximity Read ↗

Phagocytosis Checkpoints in Glioblastoma: CD47 and BeyondSemantic proximity Read ↗

Targeting CD47: the achievements and concerns of current studies on cancer immunotherapySemantic proximity Read ↗

Third-Generation Anti-CD47-Specific CAR-T Cells Effectively Kill Cancer Cells and Reduce the Genes Expression in Lung Cancer Cell MetastasisSemantic proximity Read ↗

Targeted therapies prime oncogene-driven lung cancers for macrophage-mediated destructionSemantic proximity Read ↗

Role of CD47 in tumor immunity: a potential target for combination therapySemantic proximity Read ↗

Effect of cabazitaxel on macrophages improves CD47-targeted immunotherapy for triple-negative breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.