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Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

12 Jan 2022

Abstract excerpt

There is an urgent need to understand how SARS-CoV-2 infects the airway epithelium and in a subset of individuals leads to severe illness or death. Induced pluripotent stem cells (iPSCs) provide a near limitless supply of human cells that can be differentiated into cell types of interest, including airway epithelium, for disease modeling. We present a human iPSC-derived airway epithelial platform, composed of the...

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PMID: 35020534
DOI: 10.1152/ajplung.00397.2021

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