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Article

Whole-genome mapping of APOBEC mutagenesis in metastatic urothelial carcinoma identifies driver hotspot mutations and a novel mutational signature.

Cell genomics - 10 Apr 2024

Nakauma-González J Alberto, Rijnders Maud, Noordsij Minouk T W, Martens John W M, van der Veldt Astrid A M, Lolkema Martijn P J, Boormans Joost L, van de Werken Harmen J G

Abstract excerpt

Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) enzymes mutate specific DNA sequences and hairpin-loop structures, challenging the distinction between passenger and driver hotspot mutations. Here, we characterized 115 whole genomes of metastatic urothelial carcinoma (mUC) to identify APOBEC mutagenic hotspot drivers. APOBEC-associated mutations were detected in 92% of mUCs and were...

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Share to Bladder and Urothelial Cancer Treatments
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Transitional Cell

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Source

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Identifiers

PMID: 38552621
DOI: 10.1016/j.xgen.2024.100528
PMCID: PMC11019362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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