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Integration of apaQTL and eQTL analysis reveals novel SNPs associated with occupational pulmonary fibrosis risk.

Archives of toxicology - 1 Jul 2024

Li Zhenyu, Zhang Wendi, Li Siqi, Tao Xiaobo, Xu Huiwen, Wu Yutong, Chen Qiong, Ning Anhui, Tian Tian, Zhang Lei, Cui Jiahua, Wang Wei, Chu Minjie

Abstract excerpt

To explore the association between apaQTL/eQTL-SNPs and the susceptibility to silicosis. A silicosis-related GWAS was initially conducted to screen for single nucleotide polymorphisms (SNPs) associated with the risk of silicosis. Candidate SNPs with apaQTL and eQTL functions were then obtained from the 3'aQTL-atlas and GTEx databases. Subsequently, additional case-control studies were performed to validate the...

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PMID: 38538875
DOI: 10.1007/s00204-024-03734-1

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