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Pathway analysis for a genome-wide association study of pneumoconiosis.

Toxicology letters - 5 Jan 2015

Wang Ting, Yang Jingjin, Ji Xiaoming, Chu Minjie, Zhang Ruyang, Dai Juncheng, Jin Guangfu, Hu Zhibin, Shen Hongbing, Ni Chunhui

Abstract excerpt

OBJECTIVE: The aim of this investigation was to identify pathways involved in pneumoconiosis susceptibility, clarify their potential mechanisms, and generate SNP-to-gene to pathway hypotheses using an analytical pathway-based approach. METHODS: The identify candidate causal SNPs and pathways (ICSNPathway) was used to perform pathway analysis of a GWAS dataset for pneumoconiosis, which, after quality control...

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Linkage Disequilibrium
Computational Biology
Databases, Genetic
Dust
Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inhalation Exposure

Occupational Exposure

Silicon Dioxide

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Identifiers

PMID: 25445010
DOI: 10.1016/j.toxlet.2014.10.028

Genes

TICAM1
TNF
CDH23
PTPRZ1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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