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Article

Integrating RNA-Seq With GWAS Reveals a Novel SNP in Immune-Related HLA-DQB1 Gene Associated With Occupational Pulmonary Fibrosis Risk: A Multi-Stage Study.

Frontiers in immunology - 1 Jan 2021

Zhou Yan, Zhang Yingyi, Zhao Rui, Cheng Zhounan, Tang Minzhu, Qiu Anni, Dong Yang, Lu Yihua, Lian Yulong, Zhuang Xun, Tian Tian, Wang Wei, Chu Minjie

Abstract excerpt

Objective: To evaluate the association between single-nucleotide polymorphisms (SNPs) in RNA-seq identified mRNAs and silicosis susceptibility. Methods: A comprehensive RNA-seq was performed to screen for differently expressed mRNAs in the peripheral blood lymphocytes of eight subjects exposed to silica dust (four silicosis cases and four healthy controls). Following this, the SNPs located on the shortlisted...

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Identifiers

PMID: 35111164
DOI: 10.3389/fimmu.2021.796932
PMCID: PMC8801455

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