Article
The rs2609255 polymorphism in the FAM13A gene is reproducibly associated with silicosis susceptibility in a Chinese population.
Gene - 30 Jun 2018
Wang Wei, Yu Yuhui, Wu Shuangshuang, Sang Lingli, Wang Xiaohui, Qiu Anni, Yu Xiaoqiao, Li Jingzhi, Zhang Lu, Yi Min, Zheng Huiting, Gao Yuexia, Xiao Jing, Lu Yihua, Jiang Liying, Lian Yulong, Zhuang Xun, Tian Tian, Chu Minjie
Abstract excerpt
BACKGROUND: Two recent genome-wide association studies (GWASs) reported that the FAM13A gene at the 4q22 locus associated with pulmonary fibrosis (defined by rs2609255) overlapping with COPD (defined by rs6837671). We hypothesized that single-nucleotide polymorphisms (SNPs) related to lung disease (especially pulmonary fibrosis) identified in this region are also associated with the risk of silicosis. METHODS: To...
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