Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity.

Nature - 1 Apr 2024

Ross Jason B, Myers Lara M, Noh Joseph J, Collins Madison M, Carmody Aaron B, Messer Ronald J, Dhuey Erica, Hasenkrug Kim J, Weissman Irving L

Abstract excerpt

Ageing of the immune system is characterized by decreased lymphopoiesis and adaptive immunity, and increased inflammation and myeloid pathologies1,2. Age-related changes in populations of self-renewing haematopoietic stem cells (HSCs) are thought to underlie these phenomena3. During youth, HSCs with balanced output of lymphoid and myeloid cells (bal-HSCs) predominate over HSCs with myeloid-biased output...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptive Immunity
Share to Cell Lineage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cells

Share to Lymphocytes

Share to Lymphopoiesis

Share to Myeloid Cells

Share to Myelopoiesis

Share to Viruses

Source

Open in PubMed Open full text

Identifiers

PMID: 38538791
DOI: 10.1038/s41586-024-07238-x
PMCID: PMC11870232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity.PMID 38538791Read ↗

A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cellsSemantic proximity Read ↗

The ageing haematopoietic stem cell compartment.Semantic proximity Read ↗

Reconsidering the usual suspects in age-related hematologic disorders: is stem cell dysfunction a root cause of aging?Semantic proximity Read ↗

Cell intrinsic alterations underlie hematopoietic stem cell agingSemantic proximity Read ↗

Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell CompartmentSemantic proximity Read ↗

Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice.Semantic proximity Read ↗

A Non-Invasive Stem Cell Therapy Boosts Lymphopoiesis and Averts Age-Related Blood Diseases in MiceSemantic proximity Read ↗

Single-cell profiling of immune system alterations in lymphoid, barrier and solid tissues in aged mice.Semantic proximity Read ↗

Ageing adversely affects the migration and function of marginal zone B cells.Semantic proximity Read ↗

Multiple prethymic defects underlie age-related loss of T progenitor competenceSemantic proximity Read ↗

The influence of developmental timing on B cell diversity.Semantic proximity Read ↗

Resolving Salmonella infection reveals dynamic and persisting changes in murine bone marrow progenitor cell phenotype and function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.