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Ciliary Dyneins and Dynein Related Ciliopathies

25 Jul 2021

Abstract excerpt

Although ubiquitously present, the relevance of cilia for vertebrate development and health has long been underrated. However, the aberration or dysfunction of ciliary structures or components results in a large heterogeneous group of disorders in mammals, termed ciliopathies. The majority of human ciliopathy cases are caused by malfunction of the ciliary dynein motor activity, powering retrograde intraflagellar...

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PMID: 34440654
DOI: 10.3390/cells10081885

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