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NTRK Fusions in Sarcomas: Diagnostic Challenges and Clinical Aspects

9 Mar 2021

Abstract excerpt

Tropomyosin receptor kinase (TK) is encoded by the neurotrophic tyrosine receptor kinase genes (NTRK) 1, 2, and 3, whose activation plays an important role in cell cycle proliferation and survival. Fusions of one of these genes can lead to constitutive activation of TRK, which can potentially be oncogenic. NTRK fusions are commonly present in rare histologic tumor types. Among sarcomas, infantile fibrosarcoma...

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PMID: 33803146
DOI: 10.3390/diagnostics11030478

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