NTRK1-3 Fusions in Sarcomas: Prevalence, Significance, and Clinical Implications – A Systematic Review

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose</bold> Gene fusions involving Neurotrophic Receptor Tyrosine Kinase (<italic>NTRK</italic>) genes lead to Tropomyosin Receptor Kinase (TRK) overexpression, an oncogenic mechanism rarely prevalent in soft tissue tumors. Detecting <italic>NTRK1-3</italic> fusions through advanced molecular techniques has revolutionized cancer care through personalized medicine, such as TRK i...

Topics

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• Algorithms
• Antineoplastic Agents
• CAR-T cell therapy research
• Extremities
• Gene Fusion
• Head and Neck Neoplasms
• Neurofibromatosis and Schwannoma Cases
• Sarcoma Diagnosis and Treatment

Identifiers and source

Literature Corpus work

5b15c4ec-baf0-524a-9ad3-3722b458c6b7

DOI

10.21203/rs.3.rs-6512957/v1