Article

Identification of Dual STRN-NTRK2 Rearrangements in a High Grade Sarcoma, With Good Clinical Response to First-line Larotrectinib Therapy

2023-04-19

Abstract excerpt

<h4>Background: </h4> Among the three NTRK genes, NTRK2 possesses a tremendous structural complexity and involves tumorigenesis of several types of tumors. To date, there are only STRN and RBPMS are identified in the fusion with NTRK2 in adult soft tissue tumors. More recently, the highly selective Trk tyrosine kinases inhibitors, including larotrectinib and entrectinib, have shown significant efficacy for treatin...

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Literature Corpus work: 73992503-1a2f-52de-9b75-81575fc27076
DOI: 10.21203/rs.3.rs-2817555/v1

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