Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation-Based Antibiotic Resistance Mechanism in Methicillin-Resistant Staphylococcus aureus Clinical Isolates

1 May 2021

Abstract excerpt

β-Lactam antibiotics target penicillin-binding proteins and inhibit the synthesis of peptidoglycan, a crucial step in cell wall biosynthesis. Staphylococcus aureus acquires resistance against β-lactam antibiotics by producing a penicillin-binding protein 2a (PBP2a), encoded by the mecA gene. PBP2a participates in peptidoglycan biosynthesis and exhibits a poor affinity towards β-lactam antibiotics. The current...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotic Resistance in Bacteria
Share to Antimicrobial Resistance in Staphylococcus
Share to Bacterial Identification and Susceptibility Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34062812
DOI: 10.3390/ph14050420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation-Based Antibiotic Resistance Mechanism in Methicillin-Resistant Staphylococcus aureus Clinical IsolatesPMID 34062812Read ↗

Unraveling the mechanisms of Cefoxitin resistance in methicillin-resistant Staphylococcus aureus (MRSA): structural and molecular simulation-based insights.Semantic proximity Read ↗

Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureusSemantic proximity Read ↗

Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec geneSemantic proximity Read ↗

Mechanisms of Methicillin Resistance in <i>Staphylococcus aureus</i>Semantic proximity Read ↗

Antimicrobial resistance in methicillin-resistant staphylococcus aureusSemantic proximity Read ↗

Genomic and proteomic investigation of the mechanism of antibiotic resistance in methicillin resistant Staphylococcus aureus isolated from clinical samplesSemantic proximity Read ↗

Microbiological Characteristics of Methicillin-resistant Staphylococcus aureusSemantic proximity Read ↗

Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implicationsSemantic proximity Read ↗

Methicillin-resistant Staphylococcus aureus has phenotypic variation in mecA expression that alters antibiotic sensitivity.Semantic proximity Read ↗

A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant <em>Staphylococcus aureus</em> (MRSA)Semantic proximity Read ↗

The Gly152Val mutation possibly confers resistance to beta-lactam antibiotics in ovine Staphylococcus aureus isolates.Semantic proximity Read ↗

Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.