Growth factor independence underpins a paroxysmal, aggressive Wnt5aHigh/EphA2Low phenotype in glioblastoma stem cells, conducive to experimental combinatorial therapy.

doi:10.1186/s13046-022-02333-1

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Article

Growth factor independence underpins a paroxysmal, aggressive Wnt5aHigh/EphA2Low phenotype in glioblastoma stem cells, conducive to experimental combinatorial therapy.

Journal of experimental & clinical cancer research : CR - 12 Apr 2022

Trivieri Nadia, Visioli Alberto, Mencarelli Gandino, Cariglia Maria Grazia, Marongiu Laura, Pracella Riccardo, Giani Fabrizio, Soriano Amata Amy, Barile Chiara, Cajola Laura, Copetti Massimiliano, Palumbo Orazio, Legnani Federico, DiMeco Francesco, Gorgoglione Leonardo, Vescovi Angelo L, Binda Elena

Abstract excerpt

BACKGROUND: Glioblastoma multiforme (GBM) is an incurable tumor, with a median survival rate of only 14-15 months. Along with heterogeneity and unregulated growth, a central matter in dealing with GBMs is cell invasiveness. Thus, improving prognosis requires finding new agents to inhibit key multiple pathways, even simultaneously. A subset of GBM stem-like cells (GSCs) may account for tumorigenicity,...

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PMID: 35414102
DOI: 10.1186/s13046-022-02333-1
PMCID: PMC9004109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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