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CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer´s disease

13 Sept 2023

Abstract excerpt

Diagnosis of dementia with Lewy bodies (DLB) is challenging and specific biofluid biomarkers are highly needed. We employed proximity extension-based assays to measure 665 proteins in the cerebrospinal fluid (CSF) from patients with DLB (n = 109), Alzheimer´s disease (AD, n = 235) and cognitively unimpaired controls (n = 190). We identified over 50 CSF proteins dysregulated in DLB, enriched in myelination...

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Alzheimer's disease research and treatments
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37704597
DOI: 10.1038/s41467-023-41122-y

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