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Article

Nonmuscle myosin IIA (NMIIA) regulates anisotropic cell tension to maintain the hexagonal packing of mouse lens meridional row cells.

Molecular biology of the cell - 1 Oct 2025

Islam Sadia T, Tang Yiwen, Boliver Heather, Bi Dapeng, Fowler Velia M

Abstract excerpt

The mouse ocular lens is an excellent vertebrate model for epithelial cell hexagonal packing during tissue morphogenesis. As lens epithelial cells differentiate into fiber cells, the epithelial cells rearrange into hexagonally packed meridional row (MR) cells that further differentiate to form fiber cells. We previously reported that the nonmuscle myosin IIA (NMIIA)-E1841K mutation, which alters NMIIA bipolar...

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Identifiers

PMID: 40833808
DOI: 10.1091/mbc.E25-04-0154
PMCID: PMC12483326

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