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Article

Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia.

Developmental biology - 15 Feb 2010

Sugiyama Yuki, Stump Richard J W, Nguyen Anke, Wen Li, Chen Yongjuan, Wang Yanshu, Murdoch Jennifer N, Lovicu Frank J, McAvoy John W

Abstract excerpt

Planar cell polarity (PCP) signaling polarises cells along tissue axes. Although pathways involved are becoming better understood, outstanding issues include; (i) existence/identity of cues that orchestrate global polarisation in tissues, and (ii) the generality of the link between polarisation of primary cilia and asymmetric localisation of PCP proteins. Mammalian lenses are mainly comprised of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, G-Protein-Coupled

Source

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Identifiers

PMID: 19968984
DOI: 10.1016/j.ydbio.2009.11.033
PMCID: PMC2815166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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