Urine steroid metabolomics as a diagnostic tool in primary aldosteronism.

doi:10.1016/j.jsbmb.2023.106445

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Article

Urine steroid metabolomics as a diagnostic tool in primary aldosteronism.

The Journal of steroid biochemistry and molecular biology - 1 Mar 2024

Prete Alessandro, Lang Katharina, Pavlov David, Rhayem Yara, Sitch Alice J, Franke Anna S, Gilligan Lorna C, Shackleton Cedric H L, Hahner Stefanie, Quinkler Marcus, Dekkers Tanja, Deinum Jaap, Reincke Martin, Beuschlein Felix, Biehl Michael, Arlt Wiebke

Abstract excerpt

Primary aldosteronism (PA) causes 5-10% of hypertension cases, but only a minority of patients are currently diagnosed and treated because of a complex, stepwise, and partly invasive workup. We tested the performance of urine steroid metabolomics, the computational analysis of 24-hour urine steroid metabolome data by machine learning, for the identification and subtyping of PA. Mass spectrometry-based...

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