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Article

Aberrant inflammatory responses to type I interferon in STAT2 or IRF9 deficiency

16 Feb 2022

Abstract excerpt

BACKGROUND: Inflammatory phenomena such as hyperinflammation or hemophagocytic lymphohistiocytosis are a frequent yet paradoxical accompaniment to virus susceptibility in patients with impairment of type I interferon (IFN-I) signaling caused by deficiency of signal transducer and activator of transcription 2 (STAT2) or IFN regulatory factor 9 (IRF9). OBJECTIVE: We hypothesized that altered and/or prolonged IFN-I...

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PMID: 35182547
DOI: 10.1016/j.jaci.2022.01.026

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