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Article

Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56bright subset

30 Jan 2013

Abstract excerpt

Mutations in the transcription factor GATA2 underlie the syndrome of monocytopenia and B- and natural killer (NK)-cell lymphopenia associated with opportunistic infections and cancers. In addition, patients have recurrent and severe viral infections. NK cells play a critical role in mediating antiviral immunity. Human NK cells are thought to mature in a linear fashion, with the CD56(bright) stage preceding...

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PMID: 23365458
DOI: 10.1182/blood-2012-09-453969

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