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Article

Risk prediction and interaction analysis using polygenic risk score of type 2 diabetes in a Korean population.

Scientific reports - 21 Mar 2024

Song Minsun, Kwak Soo Heon, Kim Jihyun

Abstract excerpt

Joint modelling of genetic and environmental risk factors can provide important information to predict the risk of type 2 diabetes (T2D). Therefore, to predict the genetic risk of T2D, we constructed a polygenic risk score (PRS) using genotype data of one Korean cohort, KARE (745 cases and 2549 controls), and the genome-wide association study summary statistics of Biobank Japan. We evaluated the performance of...

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Identifiers

PMID: 38514700
DOI: 10.1038/s41598-024-55945-2
PMCID: PMC10957984

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