Alzheimer's Disease Sequencing Project release 4 whole genome sequencing dataset.

doi:10.1002/alz.70237

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Alzheimer's Disease Sequencing Project release 4 whole genome sequencing dataset.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2025

Leung Yuk Yee, Lee Wan-Ping, Kuzma Amanda B, Nicaretta Heather, Valladares Otto, Gangadharan Prabhakaran, Qu Liming, Zhao Yi, Ren Youli, Cheng Po-Liang, Kuksa Pavel P, Wang Hui, White Heather, Katanic Zivadin, Bass Lauren, Saravanan Naveen, Greenfest-Allen Emily, Kirsch Maureen, Cantwell Laura, Iqbal Taha, Wheeler Nicholas R, Farrell John J, Zhu Congcong, Turner Shannon L, Gunasekaran Tamil I, Mena Pedro R, Jin Yumi, Carter Luke, Zhang Xiaoling, Vardarajan Badri N, Toga Arthur, Cuccaro Michael, Hohman Timothy J, Bush William S, Naj Adam C, Martin Eden, Dalgard Clifton L, Kunkle Brian W, Farrer Lindsay A, Mayeux Richard P, Haines Jonathan L, Pericak-Vance Margaret A, Schellenberg Gerard D, Wang Li-San

Abstract excerpt

INTRODUCTION: The Alzheimer's Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Alzheimer's disease and related dementias (ADRD) by integrating whole genome sequencing (WGS) with other genetic, phenotypic, and harmonized datasets from diverse populations. METHODS: The Genome Center for Alzheimer's Disease (GCAD) uniformly processed WGS from 36,361 ADSP samples,...

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PMID: 40407102
DOI: 10.1002/alz.70237
PMCID: PMC12100500

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