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Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum

20 Mar 2024

Abstract excerpt

Malaria genomic surveillance often estimates parasite genetic relatedness using metrics such as Identity-By-Decent (IBD), yet strong positive selection stemming from antimalarial drug resistance or other interventions may bias IBD-based estimates. In this study, we use simulations, a true IBD inference algorithm, and empirical data sets from different malaria transmission settings to investigate the extent of...

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PMID: 38509066
DOI: 10.1038/s41467-024-46659-0

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