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Strong Positive Selection Biases Identity-By-Descent-Based Inferences of Recent Demography and Population Structure in <i>Plasmodium falciparum</i>

2023-07-15

Abstract excerpt

Malaria genomic surveillance often estimates parasite genetic relatedness using metrics such as Identity-By-Decent (IBD). Yet, strong positive selection stemming from antimalarial drug resistance or other interventions may bias IBD-based estimates. In this study, we utilized simulations, a true IBD inference algorithm, and empirical datasets from different malaria transmission settings to investigate the extent of...

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Literature Corpus work
63df3f07-93c5-5f8d-b996-176258fc4840
DOI
10.1101/2023.07.14.549114
Open publication

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Strong Positive Selection Biases Identity-By-Descent-Based Inferences of Recent Demography and Population Structure in <i>Plasmodium falciparum</i>DOI 10.1101/2023.07.14.549114
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