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Article

Puzzling phenomenon: adult-onset cancer predisposition and pediatric cancer.

Trends in cancer - 1 Jun 2024

Kuhlen Michaela, Hofmann Thomas G, Golas Monika M

Abstract excerpt

Pathogenic variants (PVs) in DNA repair-linked adult-onset cancer predisposition genes, including double heterozygosity, are increasingly identified in pediatric patients with cancer. Their role in childhood cancer, however, remains poorly understood. Integrating comprehensive tumor analysis is integral for understanding the contribution of such PVs in cancer development and personalized cancer care.

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Identifiers

PMID: 38503638
DOI: 10.1016/j.trecan.2024.02.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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