The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms.

doi:10.1038/s41467-021-21255-8

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Article

The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms.

Nature communications - 12 Feb 2021

Schwartz Jason R, Ma Jing, Kamens Jennifer, Westover Tamara, Walsh Michael P, Brady Samuel W, Robert Michael J, Chen Xiaolong, Montefiori Lindsey, Song Guangchun, Wu Gang, Wu Huiyun, Branstetter Cristyn, Hiltenbrand Ryan, Walsh Michael F, Nichols Kim E, Maciaszek Jamie L, Liu Yanling, Kumar Priyadarshini, Easton John, Newman Scott, Rubnitz Jeffrey E, Mullighan Charles G, Pounds Stanley, Zhang Jinghui, Gruber Tanja, Ma Xiaotu, Klco Jeffery M

Abstract excerpt

Pediatric therapy-related myeloid neoplasms (tMN) occur in children after exposure to cytotoxic therapy and have a dismal prognosis. The somatic and germline genomic alterations that drive these myeloid neoplasms in children and how they arise have yet to be comprehensively described. We use whole exome, whole genome, and/or RNA sequencing to characterize the genomic profile of 84 pediatric tMN cases (tMDS:...

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Identifiers

PMID: 33579957
DOI: 10.1038/s41467-021-21255-8
PMCID: PMC7880998

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Source receipt: pubmed, retrieved 6 Sept 2026.

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