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Article

Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Nov 2008

Choi Doo-Sup, Wei Weizheng, Deitchman J Kevin, Kharazia Viktor N, Lesscher Heidi M B, McMahon Thomas, Wang Dan, Qi Zhan-Heng, Sieghart Werner, Zhang Chao, Shokat Kevan M, Mody Istvan, Messing Robert O

Abstract excerpt

Ethanol alters the distribution and abundance of PKCdelta in neural cell lines. Here we investigated whether PKCdelta also regulates behavioral responses to ethanol. PKCdelta(-/-) mice showed reduced intoxication when administered ethanol and reduced ataxia when administered the nonselective GABA(A) receptor agonists pentobarbital and pregnanolone. However, their response to flunitrazepam was not altered,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19005054
DOI: 10.1523/JNEUROSCI.3156-08.2008
PMCID: PMC2688726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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