Article
Targeting ESE3/EHF With Nifurtimox Inhibits CXCR2+ Neutrophil Infiltration and Overcomes Pancreatic Cancer Resistance to Chemotherapy and Immunotherapy.
Gastroenterology - 1 Jul 2024
Xie Yongjie, Zhou Tianxing, Li Xueyang, Zhao Kaili, Bai Weiwei, Hou Xupeng, Liu Ziyun, Ni Bo, Zhang Zhaoyu, Yan Jingrui, Wang Yifei, Jiang Wenna, Wang Hongwei, Chang Antao, Gao Song, Zhao Tiansuo, Yang Shengyu, Huang Chongbiao, Liu Jing, Hao Jihui
Abstract excerpt
BACKGROUND & AIMS: Because pancreatic cancer responds poorly to chemotherapy and immunotherapy, it is necessary to identify novel targets and compounds to overcome resistance to treatment. METHODS: This study analyzed genomic single nucleotide polymorphism sequencing, single-cell RNA sequencing, and spatial transcriptomics. Ehf-knockout mice, KPC (LSL-KrasG12D/+, LSL-Trp53R172H/+ and Pdx1-Cre) mice, CD45.1+...
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