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Article

Precise analysis of the effect of basal core promoter/precore mutations on the main phenotype of chronic hepatitis B in mouse models.

Journal of medical virology - 1 Dec 2020

Liu Yang, Zhao Zhong Hua, Lv Xiao Qin, Tang Yu Wei, Cao Min, Xiang Qin, Wu Yue, Zhang Hua Tang, Lai Guo Qi

Abstract excerpt

High replication and mutation rates of hepatitis B virus (HBV) often lead to reduced or suppressed hepatitis B e antigen expression. The most common mutations are genomic variations in the basal core promoter (BCP) and pre-core (PC) regions. However, the effect of BCP/PC mutations on HBV phenotype in vivo remains unclear. We compared and analyzed BCP/PC mutations and BCP/PC reverse mutations in mouse models. In...

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PMID: 32427358
DOI: 10.1002/jmv.26025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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