Article
HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice.
Hepatology (Baltimore, Md.) - 1 Sept 2023
Uchida Takuro, Imamura Michio, Hayes C Nelson, Suehiro Yosuke, Teraoka Yuji, Ohya Kazuki, Aikata Hiroshi, Abe-Chayama Hiromi, Ishida Yuji, Tateno Chise, Hara Yuichi, Hino Keisuke, Okamoto Toru, Matsuura Yoshiharu, Aizaki Hideki, Wake Kenjiro, Kohara Michinori, Liang T Jake, Oka Shiro, Chayama Kazuaki
Abstract excerpt
BACKGROUND AND AIMS: Mutations within the precore (PC) and basal core promoter (BCP) regions of the HBV genome are associated with fulminant hepatitis and HBV reactivation. These mutations may enhance viral replication, but little is known about whether they directly induce damage to the liver. We investigated mechanisms of direct cytopathic effects induced by the infection with PC/BCP mutants in the absence of...
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