Article
Precore mutation of hepatitis B virus may contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis.
PloS one - 1 Jan 2012
Liao Yun, Hu Xin, Chen Jie, Cai Bei, Tang Jiangtao, Ying Binwu, Wang Haiqing, Wang Lanlan
Abstract excerpt
BACKGROUND: Studies focused on the correlation of mutations in the genome of Hepatitis B Virus (HBV) like Pre-S mutation, Basal Core promoter (BCP), Enhancer II (EnhII), especially Precore mutation, with the risk of hepatocellular carcinoma (HCC) have triggered stiff controversies. With an increasing number of studies in this field recently, we conducted this meta-analysis to appraise the correlations. METHODS:...
Topics
- Amino Acid Substitution
- Carcinoma, Hepatocellular
- Confidence Intervals
- Gene Deletion
- Genetic Heterogeneity
- Genetic Predisposition to Disease
- Genome, Viral
- Hepatitis B virus
- Humans
- Liver Neoplasms