IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3

Abstract excerpt

<title>Abstract</title> <p>Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in preterm infants, characterised by compromised alveolar development and pulmonary vascular abnormalities. Emerging evidence suggests that regulatory T cells (Tregs) may confer protective effects on the vasculature. Knockdown of their transcription factor, interferon regulatory factor 4 (IRF4), has been shown...

Topics

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• Alveolar Epithelial Cells
• Bronchopulmonary Dysplasia
• Forkhead Transcription Factors
• Hyperoxia
• Interferon Regulatory Factors
• Interleukin-17
• Nuclear Receptor Subfamily 1, Group F, Member 3
• T-Lymphocytes, Regulatory

Identifiers and source

Literature Corpus work

71d96536-7600-55a6-82ed-79fc9b522023

DOI

10.21203/rs.3.rs-3410701/v1