Article
Apolipoprotein E genetic variation, atherogenic index and cardiovascular disease risk assessment in an African population: An analysis of HIV and malaria patients in Ghana.
PloS one - 1 Jan 2023
Thomford Nicholas Ekow, Anyanful Akwasi, Ateko Richmond Owusu, Blackhurst Dee, Biney Robert Peter, Boadi Dennis, Nyarko Samuel Badu, Ekor Martins, Kyei George Boateng
Abstract excerpt
BACKGROUND: Apolipoprotein E is involved in lipid transport and clearance of lipoprotein through low-density lipoprotein receptors (LDLR). ApoE variation has been linked to cardiovascular disease (CVD) risk. There are 3 isoforms of ApoE which originate from two non-synonymous single nucleotide polymorphisms denoted as ε2, ε3 and ε4. The ε2 isoform is implicated in higher levels of atherogenic lipoprotein with the...
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