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Article

Unravelling the Role of PAX2 Mutation in Human Focal Segmental Glomerulosclerosis

1 Dec 2021

Abstract excerpt

No effective treatments are available for familial steroid-resistant Focal Segmental Glomerulosclerosis (FSGS), characterized by proteinuria due to ultrastructural abnormalities in glomerular podocytes. Here, we studied a private PAX2 mutation identified in a patient who developed FSGS in adulthood. By generating adult podocytes using patient-specific induced pluripotent stem cells (iPSC), we developed an in...

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PMID: 34944624
DOI: 10.3390/biomedicines9121808

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