Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Viral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3.

PloS one - 1 Jan 2011

Lai Yvonne, Yi Guanghui, Chen Alice, Bhardwaj Kanchan, Tragesser Brady J, Rodrigo A Valverde, Zlotnick Adam, Mukhopadhyay Suchetana, Ranjith-Kumar C T, Kao C Cheng

Abstract excerpt

Toll-like Receptor 3 (TLR3) detects double-stranded (ds) RNAs to activate innate immune responses. While poly(I:C) is an excellent agonist for TLR3 in several cell lines and in human peripheral blood mononuclear cells, viral dsRNAs tend to be poor agonists, leading to the hypothesis that additional factor(s) are likely required to allow TLR3 to respond to viral dsRNAs. TLR3 signaling was examined in a lung...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capsid Proteins
Share to Endosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Poly I-C

Share to RNA-Binding Proteins

Share to RNA-Dependent RNA Polymerase

Share to RNA, Double-Stranded

Share to Toll-Like Receptor 3

Source

Open in PubMed Open full text

Identifiers

PMID: 22016778
DOI: 10.1371/journal.pone.0025837
PMCID: PMC3189932

Genes

TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Viral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3.PMID 22016778Read ↗

Toll-like receptor 3 mediates establishment of an antiviral state against hepatitis C virus in hepatoma cells.Semantic proximity Read ↗

Sensing of Viral Infection and Activation of Innate Immunity by Toll-Like Receptor 3Semantic proximity Read ↗

Toll-Like Receptor 3 Is Induced by and Mediates Antiviral Activity against Rhinovirus Infection of Human Bronchial Epithelial CellsSemantic proximity Read ↗

Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus ReplicationSemantic proximity Read ↗

Interaction of Hepatitis C virus proteins with pattern recognition receptorsSemantic proximity Read ↗

Activation of Pattern Recognition Receptor-Mediated Innate Immunity Inhibits the Replication of Hepatitis B Virus in Human Hepatocyte-Derived CellsSemantic proximity Read ↗

RIG-I and dsRNA-Induced IFNβ ActivationSemantic proximity Read ↗

Early Innate Immune Responses to Sin Nombre Hantavirus Occur Independently of IFN Regulatory Factor 3, Characterized Pattern Recognition Receptors, and Viral EntrySemantic proximity Read ↗

The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.Semantic proximity Read ↗

Characterization of RNA Sensing Pathways in Hepatoma Cell Lines and Primary Human HepatocytesSemantic proximity Read ↗

Toll-Like Receptor 3 Signaling on Macrophages Is Required for Survival Following Coxsackievirus B4 InfectionSemantic proximity Read ↗

Kinetic Differences and Synergistic Antiviral Effects Between Type I and Type III Interferon Signaling Indicate Pathway IndependenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.