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Article

Prefrontal Cortex Cytosolic Proteome and Machine Learning-Based Predictors of Resilience toward Chronic Social Isolation in Rats.

International journal of molecular sciences - 6 Mar 2024

Filipović Dragana, Novak Božidar, Xiao Jinqiu, Tadić Predrag, Turck Christoph W

Abstract excerpt

Chronic social isolation (CSIS) generates two stress-related phenotypes: resilience and susceptibility. However, the molecular mechanisms underlying CSIS resilience remain unclear. We identified altered proteome components and biochemical pathways and processes in the prefrontal cortex cytosolic fraction in CSIS-resilient rats compared to CSIS-susceptible and control rats using liquid chromatography coupled with...

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Identifiers

PMID: 38474271
DOI: 10.3390/ijms25053026
PMCID: PMC10931671

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