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Article

Prefrontal cortical synaptoproteome profile combined with machine learning predicts resilience towards chronic social isolation in rats.

Journal of psychiatric research - 1 Apr 2024

Filipović Dragana, Novak Božidar, Xiao Jinqiu, Tadić Predrag, Turck Christoph W

Abstract excerpt

Chronic social isolation (CSIS) of rats serves as an animal model of depression and generates CSIS-resilient and CSIS-susceptible phenotypes. We aimed to investigate the prefrontal cortical synaptoproteome profile of CSIS-resilient, CSIS-susceptible, and control rats to delineate biochemical pathways and predictive biomarker proteins characteristic for the resilient phenotype. A sucrose preference test was...

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PMID: 38412784
DOI: 10.1016/j.jpsychires.2024.02.042

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