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Article

TNFRSF1B Gene Variants in Clinicopathological Aspects and Prognosis of Patients with Cutaneous Melanoma.

International journal of molecular sciences - 1 Mar 2024

Carvalho Bruna Fernandes, Gomez Gabriela Vilas Bôas, Carron Juliana, Macedo Ligia Traldi, Gonçalves Gisele Melo, Vazquez Vinicius de Lima, Serrano Sergio Vicente, Lourenço Gustavo Jacob, Lima Carmen Silvia Passos

Abstract excerpt

Regulatory T lymphocytes play a critical role in immune regulation and are involved in the aberrant cell elimination by facilitating tumor necrosis factor connection to the TNFR2 receptor, encoded by the TNFRSF1B polymorphic gene. We aimed to examine the effects of single nucleotide variants TNFRSF1B c.587T>G, c.*188A>G, c.*215C>T, and c.*922C>T on the clinicopathological characteristics and survival of cutaneous...

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Identifiers

PMID: 38474115
DOI: 10.3390/ijms25052868
PMCID: PMC10932403

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