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Article

Influence of IL1B (rs16944) and IL1R2 (rs4141134) polymorphisms on aggressiveness and prognosis of cutaneous melanoma.

Melanoma research - 1 Oct 2021

Torricelli Caroline, Carron Juliana, Carvalho Bruna Fernandes, Macedo Ligia Traldi, Rinck-Junior José Augusto, Lima Carmen Silvia Passos, Lourenço Gustavo Jacob

Abstract excerpt

Cutaneous melanoma is the most aggressive skin cancer with high mortality. Proinflammatory cytokines can modulate the proliferation and survival of cutaneous melanoma cells. Higher levels of interleukin-1β (IL1B) were associated with tumor cell proliferation, invasion, and migration, and the IL-1 type II receptor (IL1R2) serves as an endogenous inhibitor of IL1B signaling. Single-nucleotide variations (SNVs) in...

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PMID: 34284461
DOI: 10.1097/CMR.0000000000000763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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