Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic analysis of mycosis fungoides and Sézary syndrome identifies recurrent alterations in TNFR2.

Nature genetics - 1 Sept 2015

Ungewickell Alexander, Bhaduri Aparna, Rios Eon, Reuter Jason, Lee Carolyn S, Mah Angela, Zehnder Ashley, Ohgami Robert, Kulkarni Shashikant, Armstrong Randall, Weng Wen-Kai, Gratzinger Dita, Tavallaee Mahkam, Rook Alain, Snyder Michael, Kim Youn, Khavari Paul A

Abstract excerpt

Mycosis fungoides and Sézary syndrome comprise the majority of cutaneous T cell lymphomas (CTCLs), disorders notable for their clinical heterogeneity that can present in skin or peripheral blood. Effective treatment options for CTCL are limited, and the genetic basis of these T cell lymphomas remains incompletely characterized. Here we report recurrent point mutations and genomic gains of TNFRSF1B, encoding the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bortezomib
Share to CD28 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CTLA-4 Antigen

Share to Drug Resistance, Neoplasm

Share to Mycosis Fungoides

Share to Oncogene Proteins, Fusion

Share to Receptors, Tumor Necrosis Factor, Type II

Share to Skin Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 26258847
DOI: 10.1038/ng.3370
PMCID: PMC6091217

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic analysis of mycosis fungoides and Sézary syndrome identifies recurrent alterations in TNFR2.PMID 26258847Read ↗

Genomic profiling of mycosis fungoides identifies patients at high risk of disease progression.Semantic proximity Read ↗

Integrative Mutational Landscape of Mycosis Fungoides Using a National Genomics RepositorySemantic proximity Read ↗

Clinical and functional characterization of a novel TNFRSF9 variant causing immune dysregulation with predisposition to EBV-driven lymphomagenesisSemantic proximity Read ↗

Integrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity.Semantic proximity Read ↗

Pathogenic variants of mycosis fungoides identified using next-generation sequencing.Semantic proximity Read ↗

New Insights Into the Complex Mutational Landscape of Sézary SyndromeSemantic proximity Read ↗

Single-cell RNA sequencing comparison of CD4+, CD8+ and T-cell receptor γδ+ cutaneous T-cell lymphomas reveals subset-specific molecular phenotypes.Semantic proximity Read ↗

Cell signaling in cutaneous T‐cell lymphoma microenvironment: promising targets for molecular‐specific treatmentSemantic proximity Read ↗

Genetic profiles and clinical features in subcutaneous panniculitis-like T-cell lymphomas.Semantic proximity Read ↗

Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides.Semantic proximity Read ↗

An Update on Molecular Biology of Cutaneous T Cell LymphomaSemantic proximity Read ↗

Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.